Obesity and Gut Microbiota: a Succinct Evaluation

Abstract

Obesity has been of global health concern, contributing to a wide range of chronic diseases such as cardiovascular disease, type 2 diabetes, and certain cancers. Recent research has illuminated the complex role of gut microbiota in the development and progression of obesity The gut microbiota tempers host metabolism through mechanisms like fermentation of dietary fibers, production of short-chain fatty acids, and regulation of appetite-related hormones. Addressing obesity through a microbiota-centric approach necessitates comprehensive strategies that integrate dietary modifications, lifestyle intervention and consideration of culture. The gut microbiota affects metabolism and immune function which are crucial for energy regulation and fat storage. This review examines the interplay between obesity and dysbiosis, emphasizing the critical roles of diet and lifestyle as understanding these dynamics informs tailored interventions for obesity prevention and management.

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References

Ryan, D., Barquera, S., Barata Cavalcanti, O., & Ralston, J. (2021). The global pandemic of overweight and obesity: addressing a twenty-first century multifactorial disease. In Handbook of global health (pp. 739-773). Cham: Springer International Publishing.

Mohajan, D., & Mohajan, H. (2023). Obesity and Its Related Diseases: A New Escalating Alarming in Global Health. Journal of Innovations in Medical Research. https://doi.org/10.56397/jimr/2023.03.04.

Freedman, D.S., Goodwin Davies, A.J., Phan, T.L.T., Cole, F.S., Pajor, N., Rao, S., Eneli, I., Kompaniyets, L., Lange, S.J., Christakis, D.A. and Forrest, C.B., 2022. Measuring BMI change among children and adolescents. Pediatric obesity, 17(6), p.e12889.

Switala, K. and Leonska-Duniec, A., 2021. Physical activity and gene association with human obesity. Baltic Journal of Health and Physical Activity, 13(4), p.10.

Moradi, M., Mozaffari, H., Askari, M. and Azadbakht, L., 2021. Association between overweight/obesity with depression, anxiety, low self-esteem, and body dissatisfaction in children and adolescents: a systematic review and meta-analysis of observational studies. Critical Reviews in Food Science and Nutrition, 62(2), pp.555-570.

Yoon, J., , J., Velankanni, P., Lee, C., & Kwon, H. (2023). Gut Microbial Metabolites on Host Immune Responses in Health and Disease. Immune Network, 23. https://doi.org/10.4110/in.2023.23.e6.

Amabebe, E., Robert, F.O., Agbalalah, T. and Orubu, E.S., 2020. Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism. British Journal of Nutrition, 123(10), pp.1127-1137.

Breton, J., Galmiche, M., & Déchelotte, P. (2022). Dysbiotic Gut Bacteria in Obesity: An Overview of the Metabolic Mechanisms and Therapeutic Perspectives of Next-Generation Probiotics. Microorganisms, 10. https://doi.org/10.3390/microorganisms10020452.

Pinto, A., Cavalcante, D., Araújo, E., Cabral, F., Santos, J., & Costa, K. (2021). Dysbiosis and obesity: implications of the gut microbiota. International Journal of Nutrology. https://doi.org/10.54448/ijn2135.

Magne, F., Gotteland, M., Gauthier, L., Zazueta, A., Pesoa, S., Navarrete, P., & Balamurugan, R. (2020). The firmicutes/bacteroidetes ratio: a relevant marker of gut dysbiosis in obese patients?. Nutrients, 12(5), 147

Tian, S., Chu, Q., , S., , H., & Song, H. (2023). Dietary Fiber and Its Potential Role in Obesity: A Focus on Modulating the Gut Microbiota.. Journal of agricultural and food chemistry. https://doi.org/10.1021/acs.jafc.3c03923.

Peredo-Lovillo, A., Romero-Luna, H., & Jiménez‐Fernández, M. (2020). Health promoting microbial metabolites produced by gut microbiota after prebiotics metabolism. Food research international, 136, 109473 . https://doi.org/10.1016/j.foodres.2020.109473.

Singh, V., Lee, G., Son, H., Koh, H., Kim, E., Unno, T., & Shin, J. (2023). Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics. Frontiers in Microbiology, 13. https://doi.org/10.3389/fmicb.2022.1103836.

Qadir, R., & Assafi, M. (2021). The association between body mass index and the oral Firmicutes and Bacteroidetes profiles of healthy individuals.. Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia, 16 3, 36-43 . https://doi.org/10.51866/oa1129.

Katz-Agranov, N., & Zandman-Goddard, G. (2021). The microbiome links between aging and lupus.. Autoimmunity reviews, 102765 . https://doi.org/10.1016/j.autrev.2021.102765.

Oliver, A., Chase, A. B., Weihe, C., Orchanian, S. B., Riedel, S. F., Hendrickson, C. L., ... & Whiteson, K. (2021). High-fiber, whole-food dietary intervention alters the human gut microbiome but not fecal short-chain fatty acids. Msystems, 6(2), 10-1128

Yu, M., Ding, H., Gong, S., Luo, Y., Lin, H., Mu, Y., Li, H., Li, X., & Zhong, M. (2023). Fungal dysbiosis facilitates inflammatory bowel disease by enhancing CD4+ T cell glutaminolysis. Frontiers in Cellular and Infection Microbiology, 13. https://doi.org/10.3389/fcimb.2023.1140757.

Nogal, A., Valdes, A., & Menni, C. (2021). The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health. Gut Microbes, 13. https://doi.org/10.1080/19490976.2021.1897212.

Recharla, N., Geesala, R., & Shi, X. (2023). Gut Microbial Metabolite Butyrate and Its Therapeutic Role in Inflammatory Bowel Disease: A Literature Review. Nutrients, 15. https://doi.org/10.3390/nu15102275.

Schalla, M., & Stengel, A. (2020). Effects of microbiome changes on endocrine ghrelin signaling – A systematic review. Peptides, 133. https://doi.org/10.1016/j.peptides.2020.170388.

Serek, P., & Oleksy-Wawrzyniak, M. (2021). The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity. International Journal of Molecular Sciences, 22. https://doi.org/10.3390/ijms222111359.

Chancharoenthana, W., Kamolratanakul, S., Schultz, M., & Leelahavanichkul, A. (2023). The leaky gut and the gut microbiome in sepsis – targets in research and treatment. Clinical Science (London, England : 1979), 137, 645 - 662. https://doi.org/10.1042/CS20220777.

Uebanso, T., Shimohata, T., Mawatari, K., & Takahashi, A. (2020). Functional Roles of B-Vitamins in the Gut and Gut Microbiome.. Molecular nutrition & food research, e2000426 . https://doi.org/10.1002/mnfr.202000426.

Dimidi, E., Cox, S. R., Rossi, M., & Whelan, K. (2019). Fermented foods: definitions and characteristics, impact on the gut microbiota and effects on gastrointestinal health and disease. Nutrients, 11(8), 1806.

Martel, J., Chang, S. H., Ko, Y. F., Hwang, T. L., Young, J. D., & Ojcius, D. M. (2022). Gut barrier disruption and chronic disease. Trends in Endocrinology & Metabolism, 33(4), 247-265

Lin, K., Zhu, L., & Yang, L. (2022). Gut and obesity/metabolic disease: focus on microbiota metabolites. MedComm, 3(3), e171.

Huang, Y., Wang, Z., Ma, H., Ji, S., Chen, Z., Cui, Z., Chen, J. and Tang, S., 2021. Dysbiosis and implication of the gut microbiota in diabetic retinopathy. Frontiers in Cellular and Infection Microbiology, 11, p.646348.

Amabebe, E., Robert, F.O., Agbalalah, T. and Orubu, E.S., 2020. Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism. British Journal of Nutrition, 123(10), pp.1127-1137.

Milano, W., Carizzone, F., Foia, M., Marchese, M., Milano, M., Saetta, B., & Capasso, A. (2022). Obesity and Its Multiple Clinical Implications between Inflammatory States and Gut Microbiotic Alterations. Diseases, 11(1), 7.

Crovesy, L., Masterson, D., & Rosado, E. (2020). Profile of the gut microbiota of adults with obesity: a systematic review. European Journal of Clinical Nutrition, 1-12. https://doi.org/10.1038/s41430-020-0607-6.

Breton, J., Galmiche, M., & Déchelotte, P. (2022). Dysbiotic gut bacteria in obesity: an overview of the metabolic mechanisms and therapeutic perspectives of next-generation probiotics. Microorganisms, 10(2), 452.

Mora-Flores, L., Casildo, R., Fuentes-Cabrera, J., Pérez-Vicente, H., De Anda-Jáuregui, G., & Neri-Torres, E. (2023). The Role of Carbohydrate Intake on the Gut Microbiome: A Weight of Evidence Systematic Review. Microorganisms, 11. https://doi.org/10.3390/microorganisms11071728.

Malesza, I. J., Malesza, M., Walkowiak, J., Mussin, N., Walkowiak, D., Aringazina, R., ... & Mądry, E. (2021). High-fat, western-style diet, systemic inflammation, and gut microbiota: a narrative review. Cells, 10(11), 3164.

Rezende, E. S. V., Lima, G. C., & Naves, M. M. V. (2021). Dietary fibers as beneficial microbiota modulators: A proposed classification by prebiotic categories. Nutrition, 89, 111217.

DOI: https://doi.org/10.46676/ij-fanres.v6i1.368